Transperineal Biopsy

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[lwptoc] What is Transperineal Biopsy Transperineal biopsy is a type of treatment in which a sample is taken from the perineum region. The region between the scrotum and anus is called the perineum region. This procedure is majorly done with ultrasound.  Transperineal biopsy is an investigation carried out to diagnose prostate cancer in males and… Read More

Transperineal Biopsy


What is Transperineal Biopsy

Transperineal biopsy is a type of treatment in which a sample is taken from the perineum region. The region between the scrotum and anus is called the perineum region. This procedure is majorly done with ultrasound. 

Transperineal biopsy is an investigation carried out to diagnose prostate cancer in males and infections or inflammation occurring in the prostate area. In this procedure, a needle is used to take out the tissue from the prostate glands. Although local anesthetics are used to numb the skin during the procedure, the pain remains for a few days.

Transperineal biopsies are secure, but some side effects include bleeding, infections, and pain. Under high-temperature conditions, difficulty passing urine, blood in urine or stool, shivering or shaking, consulting the doctor is the best suggestion.

Why is the scope of Transperineal Prostate Biopsy?

Transperineal biopsy is mainly done to treat cancer cells in the prostate gland. The main cause of prostate gland cancer is when some cells in the gland grow abnormally and cause inflammation during urination or ejaculation, erectile dysfunction, blood or urine in the sample, etc. 

In addition to biopsies, specific tests are used to determine prostate cancer, such as ERG protein marker, select Mdx, confirm Mdx, etc. There are methods to obtain much better treatment results in Transperineal prostate biopsy, such as taking antibiotics, reviewing medicines, and anesthesia, but local anesthetics lead to pain, anxiety, infection, bleeding, etc.

Transperineal Template-guided Prostate Mapping Biopsy

The process of diagnosing prostate glands and treating the cancer disease by ultrasound is called the transperineal template-guided prostate mapping technique, or template biopsy in short. In this technique, ultrasound is used for designing a map of prostate glands where the whole gland is divided into 24 sections and can be seen three-dimensionally. 

Here needles are pressed against the tissues with the help of a template into the 24 areas one by one to remove the deviated cells or the aberrant tissues. This procedure takes nearly 20 to 25 minutes. This technique of template biopsy or prostate mapping is brought by Britain, which uses MRI reports of the patient for proper diagnosis. Baraqawi is the discoverer of the 3d mapping biopsy technique. 

A map consisting of x,y, and z-axis and the position of tissues are located on these axes, and 600+ tests for prostate glands can be performed. Generally, one biopsy is enough; however, patients from 20 – 40 may require more than one biopsy. An alternative for template biopsy is the prostate cancer enzyme test; this is not the complete replacement but can identify patients who need a biopsy. 

A committee of urological surgeons in Britain formed the British Association of urological surgeons (BAUS). They have introduced PSCF, i.e., procedure-specific consent forms. These are the forms that ask for the patient’s specific information and guide you about the procedure taking place during the transurethral resection of prostate glands.

Types of Prostate Biopsy

There are different prostate biopsy types, such as transrectal ultrasound-guided systematic biopsy, transurethral biopsy, and transperineal prostate biopsy. A transurethral biopsy is done for the urinary bladder, where tissue is removed by inserting a thin tube into the bladder, i.e., with the help of a cutting loop and examined under the microscope. 

However, a Transperineal MRI fusion biopsy is the same as a transperineal biopsy test and MRI reports are needed every time to diagnose the prostate glands.


urologists are doctors that diagnose abnormality related to the urinary tract or reproductive tract. However, urology is a stream of medicine that concentrates on diseases of the urinary tract and male or female reproductive tracts. Some urologists treat the urinary system’s general diseases while others specialize in a particular type of urology, either male, female, or both.

The approach for Transperineal Biopsy Test

Initially, operations were performed by transrectal ultrasound technique; however, bleeding in the rectal part causes infection, which increases after five years from the start. The transrectal ultrasound process lasts 2 to 3 hours; however, transperineal only required 20 to 40 minutes for the procedure. An MRI test guides the transperineal biopsy test. A large magnet and radio waves work together to get the vision of organs and structures inside the body. Also, an MRI test is very much helpful in diagnosing brain and spinal cord aberrancy.

Uronav Fusion Biopsy

This diagnostic test finds out the aberrant tissues, namely cancerous cells from prostate glands, based on PSA screening tests. As the PSA levels rise, the condition of the body becomes worse. Prostate-specific antigens may be cancerous or non-cancerous. This test is done by patients diagnosed as negative during the prostate biopsy but have continued to see warning symptoms. In the biopsy tests, multiple incisions are done to the tissue with 16 to 18 thick gauge.

There are various benefits of transperineal prostate biopsy tests; the risk of infection is reduced, reduced chances of procedure-related bleeding, detection and validation of cancerous cells in the anterior part of prostate glands.

Complications with Transperineal Biopsy

  • Infection or sepsis
  • Blood in urine
  • Bruising skin of men
  • Urinary retention requiring catheter placement

Precision point of Transperineal Biopsy

The precision point is where the instrument is kept to guide the UV rays tool and revolutionizes the procedure to obtain prostate biopsies. Allaway is the instrument that guides the needle of biopsy.

Types of instrument used for Transperineal Biopsy

Transperineal biopsy is a little complicated than transrectal ultrasound biopsy and requires specialized equipment such as:

  1. Softcore automatic biopsy: a device having a guiding cannula in various gauges and lengths is called a softcore automatic device. It is used for procuring multiple samples in single insertion.
  2. Medi cut manual biopsy needle: used for manual capture of high-quality tissue samples, used for minimal trauma.
  3. Medi cure biopsy needle: this is a disposable needle with a bard’s magnum instrument; used for biopsies for soft tissues and tumors.


Why is a transperineal biopsy test carried out?

Transperineal biopsy is carried out when the patient experiences warning symptoms. A transrectal prostate biopsy is before checking prostate-specific antigen (PSA). When these antigens are not present or don’t seem to be present in the preliminary test, a transperineal biopsy test is carried out. PSA is a specific protein that is produced by foreign bodies, namely cancerous or non-cancerous cells.

Why is transperineal biopsy a more efficient procedure than others?

During the biopsy approach, a small number of blood vessels come in contact with the needle. The equipment is much accurate with specific parts and is sterilized before any needle insertion. That is why there is a low risk of infection in this case.

What is the cost of a prostate biopsy test?

The cost of a biopsy is $2,020 in total. However, on the day of the test, it is $1,110 with an additional $920 in 30 days after the biopsy procedure.

Is a transperineal biopsy painful?

Patients are usually under anesthesia when a transperineal biopsy is carried out. There may be a minimal sensation when a sample is taken, but the patient may be uncomfortable during the procedure. Regardless, antibiotics and paracetamol are given after the procedure to prevent infection and pain.

How long does a transperineal biopsy take?

The procedure is commenced in 20 to 40 minutes, but due to the administration of anesthesia, a patient might have to remain in their hospital room for a couple of hours.

What is the recovery time after a transperineal biopsy?

Doctors usually recommend a day or two of bed rest, and a patient will recover within a month. After a transperineal biopsy, you are advised not to drive or be involved in heavy exercise for 2-3 days.

When will I get the result of my biopsy?

You will get your test results after 2 to 3 weeks.