- Scars in the esophagus.
- Narrowing of the esophagus
- Damage to the esophagus
- Upper Endoscopy
- Blood Tests
- Esophageal Sponge Test
- Dietary Therapy
- Proton Pump Inhibitor
- Topical Steroids
EOSINOPHILIC ESOPHAGITIS SYMPTOMS
The signs of EoE vary with age. However, most of them are the same for both children and adults. They include:
- Swallowing difficulty (dysphagia).
- Food impaction (food getting stuck in one’s esophagus).
- Vomiting (mostly in children).
- Chest pain.
- Pains in the upper abdomen.
- Undergrowth (mostly in children).
- Weight loss.
- Lack of appetite.
- Malnutrition (poor or unhealthy feeding).
- Backflow of undigested food (regurgitation).
From the above information given, it is quite evident that the symptoms of EoE overlap with those of gastroesophageal reflux disease (GERD).
Many EoE patients are initially thought to have GERD when diagnosed, only to be found that they do not typically respond to anti-GERD therapies. People with eosinophilic esophagitis often have allergic disorders (such as asthma or eczema).
Other related disorders with almost similar symptoms with EoE include ulcerative colitis (an inflammatory bowel disease of unknown causes) and Crohn’s disease (an inflammatory bowel disease of unknown causes too).
EOSINOPHILIC ESOPHAGITIS CAUSES
Eosinophilic esophagitis flare-up is caused by the presence of a large number of eosinophils in the esophagus.
Many factors might have contributed to this production and buildup of eosinophils. Such factors may include immune hypersensitivity responses to particular foods or environmental proteins (allergens) in certain affected persons.
Genetically, some people with EoE have been found to have an extraordinarily high expression of a particular gene (known as eotaxin-3) that codes for a protein that controls the accumulation of eosinophils. Many genes have been found to contribute to EoE, including CAPN-14 and TSLP.
In normal health conditions, the esophagus is usually devoid of eosinophils. The buildup of eosinophils in the esophagus is a reaction to foods, allergens, or acid reflux.
Eosinophils are a type of disease that fights against white blood cells. They respond to conditions indicating a parasitic infection, an allergic reaction, or cancer. You can have high levels of eosinophils in tissues at the site of an infection or inflammation, apart from your blood.
Eosinophilic functions include:
- The movement to inflamed areas.
- Trapping substances.
- Killing cells.
- Anti-parasitic and bactericidal activities.
- Participating in immediate allergic reactions.
- Modulating inflammatory responses.
The accumulation of eosinophils in the esophagus (to fight allergens) can inflame or injure the esophageal tissue. The damaged esophagus can lead to difficulty in swallowing food or making food get stuck while swallowing, as well as other EoE symptoms.
What triggers eosinophilic esophagitis?
Eosinophilic esophagitis (EoE) is caused by the presence of a large of eosinophils in the esophagus. The production and pileup of eosinophils may be caused by many factors like immune hypersensitivity to certain foods or allergens, in some EoE patients.
What happens if eosinophilic esophagitis is left untreated?
If left untreated, you can eventually result in scarring and narrowing of the esophagus, which makes the symptoms even worse over time. The first step in treating EoE usually involves taking acid-blocking medications. These drugs can lower the impact of acid reflux and reduce inflammation within the esophagus.
How rare is Eosinophilic Esophagitis?
EoE is a rare disease, increasing in prevalence (with approximately 1 out of 2,000 persons affected per year). EoE affects people of all ages and ethnic composition but tends to affect males more than females.
What foods do you avoid if you have Eosinophilic Esophagitis?
The six food elimination diet (SFED) is the most frequently employed in patients with EOE. This diet typically trials the exclusion of wheat, milk, egg, nuts, soy, fish, and shellfish.
Do antihistamines help eosinophilic esophagitis?
Antihistamines are frequently used for the treatment of gastroesophageal reflux disease and allergic disorders, and we hypothesize they will be effective in the treatment of eosinophilic Esophagitis as well. The two common antihistamines are loratadine and famotidine.