- Family History
- X-rays: To reveal bone abnormalities such as bone reabsorption, enlargement of bone, and bone deformities (bending, fracture, etc.)
- Bone Scan: Carried out with a simple photon emission computed tomography (SPECT), to create a 3-D image of the affected bone to see deeper into the bones. This can indicate whether you have a bone disorder, such as cancer or arthritis, or infection in the bone.
- Blood Test: Paget’s disease of bone patients usually have high levels of alkaline phosphatase in their blood. This can be revealed by a blood test.
- The administration of osteoporosis drugs (Bisphosphonates). These drugs are of two types; oral and injection.
- Alendronate (Fosamax)
- Ibandronate (Boniva)
- Risedronate (Actonel)
- Zoledronic acid (Zometa, Reclast).
- Hormonal drug (Calcitonin); administered by injection or nasal spray
- To heal fractures
- Realign deformed bones
- Relief affected bones
- Replace damaged joints.
- Neurologic problems
- Failure of the heart
Most people who have Paget's disease of bone have no symptoms. When symptoms occur, the most common complaint is bone pain.
Paget's disease of bone has no symptoms. However, in some individuals, the most common complaint is a pain in the bone.
Signs and symptoms of Paget's disease are bone depend on the affected part of the body. Four parts are usually involved, these are:
- Pelvis; hip pains.
- Skull; loss of hearing and/or headache.
- Spine; nerve roots are compressed, resulting in pains, tingling, and numbness in the arms and legs.
- Legs; weak bones, bent or enlarged bones, osteoporosis, cartilage breakdown, and joint pains (osteoarthritis) on the knee or hip.
Because this disease causes your body to generate new bone faster than normal, the rapid remodeling produces bone that's softer and weaker than normal bone, which can lead to bone pain, deformities and fractures.
The disease might affect only one or two areas of your body or might be widespread. Your signs and symptoms, if any, will depend on the affected part of your body.
• Pelvis: Paget's disease of bone in the pelvis can cause hip pain.
• Skull: An overgrowth of bone in the skull can cause hearing loss or headaches.
• Spine: If your spine is affected, nerve roots can become compressed. This can cause pain, tingling and numbness in an arm or leg.
• Leg: As the bones weaken, they may bend causing you to become bowlegged. Enlarged and misshapen bones in your legs can put extra stress on nearby joints, which may cause osteoarthritis in your knee or hip.
Up to date, the cause of Paget's disease of bone is unknown. Scientist suggests a combination of genetic and environmental factors contribute to the disease.
Researchers have identified variations in 3 genes that are linked to Paget's disease of bone. They are:
- SQSTM 1
- TNFRSF 11A
- TNFRSF 11B
The axiological condition behind bone remodeling begins with excessive bone reabsorption followed by an increase in bone formation. A new tender bone re-emerges, weak and fragile, and can not stand harsh conditions. The weak bone develops pains and is deformed when it encounters stress and end up fractured.
Is Paget's bone disease chronic?
Paget's disease of bone is a chronic bone disorder. It has no cure but symptoms can be managed with bisphosphonates and hormonal drugs.
What does Paget's disease of the bone look like?
X-ray diagnosis provides images of dense structures such as bone. A bone affected by Paget's disease usually appears enlarged and dense than a normal bone. It may be deformed. Bones of the leg may look bowed.
What are the stages of Paget's disease?
There are 3 phases of Paget's disease of bone; lytic, mixed lytic and plastic, and sclerotic.
- Lytic lesions are spots of damaged bones that result from cancerous plasma cells building in your marrows.
- Blastic lesions are the extra cells that build up.
- Sclerotic lesions are the unusual hardening and thickening of the bones.
Is Paget's disease a form of arthritis?
People sometimes confuse Paget's disease of bone with arthritis because Paget's disease pain may be located on the part of the bone closest to a joint. However, Paget's disease can cause arthritis overtime due to extra stress on nearby joints.
How is Paget's disease of bone different from osteoporosis?
Osteoporosis involves the weakening of bones of the body. The bones are reabsorbed by the body. This abnormality affects bones in all parts of the body. However, in the case of Paget's disease of bone, the unhealthy process of bone reabsorption by the body is located in just one or a few bones.